https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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‘Of course, that's about suitable. I look for a Bodily idea of biological programs inside of a bottom-up way. I feel you could distinguish 3 strains of study in my group for the time being. The primary concerns chromosome construction: How will you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? Now we have created visualisation tactics that allow for us to study how, by way of example, SMC proteins loop DNA (movie on Youtube) so that you can Construct up chromosomes.
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2007, to start with actual-time detection of strand Trade in homologous recombination by RecA; discovery of the minimal persistence duration of ends of microtubules; and solved the system of biosensing with carbon nanotubes
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The coiled-coil on the human Rad50 DNA maintenance protein contains certain segments of elevated flexibility
We shape bacteria into sorts that deviate from their purely natural phenotype. Precisely, I'll demonstrate our capability to shape live E. coli bacteria into novel styles for instance rectangles, squares, triangles and circles.
2000, discovery that nanotubes can have extraordinary substantial current densities; settled the controversial difficulty of electronic transport as a result of DNA molecules by measurements of insulating behavior at The only molecule amount; and demonstration of an AFM approach for one-molecule manipulation of nanotubes
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At this time, we also realized that it ought to be probable cees dekker to employ only one semiconducting carbon nanotube to help make a transistor — and we established out to really make it. We stretched specific semiconducting nanotubes across metallic electrodes and employed the underlying silicon substrate as a gate electrode, setting up the basic three-terminal structure of the discipline-result transistor (Fig.
Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim of your pore is highlighted in purple, and also a 3D rendering with the motion from the DNA rod is displayed.
2001, discovery of one-electron transistors at room temperature depending on nanotubes; realization of initially logic circuits with carbon nanotube products; and discovery with the molecular composition of DNA maintenance enzymes with AFM
Allow’s 1st glance again for the time being once you chose to shift your emphasis from superconductivity and nanotubes to biology at the conclusion of the nineties.
Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and single-molecule experiments